DETECTION OF MTS1/p16 GENE EXPRESSION IN COLORECTAL CANCER BY RT-PCR
- VernacularTitle:结直肠癌组织中MTS1/p16基因表达检测的意义
- Author:
Chunlei WANG
;
Zhiqiang HUANG
;
Yanshen WANG
- Publication Type:Journal Article
- Keywords:
MTS1/p16 gene;
colorectal neoplasms;
gene deletion;
polymerase chain reaction
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the deletion of MTS1/p16 gene in human colorectal carcinoma,the homozygous deletion of MTS1/p16 gene was checked by reverse transcriptase polymerase chain reaction from 60 patients with colorectal carcinoma.The specimens consisted of 35 colorectal carcinoma,15 tumor-adjacent tissues and 10 normal colorectal mucosa. It was found that 17 14% (6/35) colorectal carcinoma specimens showed homozygous deletion of MTS1/p16 gene.No deletion was detected in tumor-adjacent tissue and normal colorectal mucosa.Deletion of MTS/p16 gene may play a role in the progression of colorectal carcinoma.
