oxLDL FUNCTIONALLY UPREGULATES GROWTH-REGULATED ONCOGENE ? EXPRESSION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
- VernacularTitle:氧化低密度脂蛋白功能性上调人脐带静脉内皮细胞的生长调节致癌基因?
- Author:
Zhubin LEI
;
Jianping LIU
;
Xiaoyan LI
- Publication Type:Journal Article
- Keywords:
oxide low density lipoprotein;
growth-regulated oncogene ?;
endothelial cells;
monocytes;
atherosclerosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of chemokine growth-regulated oncogene ? (GRO?) in process of LDL-induced atherosclerosis, a monocytic cell line, U937 cells and human umbilical vein endothelial cells were used. GRO? mRNA levels were significantly elevated after exposure of endothelial cells to oxLDL. A significant upregulation of GRO? surface expression in endothelial cells was induced by oxLDL with concentration-dependent and time-dependent manners, but no significant change in GRO? was observed in the medium. Upregulation of GRO? expression in endothelial cells enhanced monocytic cells adhesion to endothelial cells, but antibodies to GRO? inhibited the adhesion process. oxLDL functionally upregulates GRO? expression in endothelial cells.
