EXPERIMENTAL OBSERVATION FOR METABOLIC CHANGES IN GLUCOSE AND LACTIC ACID IN BIPEDICLED SEPARATION DELAYED FLAP
- VernacularTitle:阻隔皮瓣内葡萄糖、乳酸的代谢变化
- Author:
Zhongli LI
;
Boxun ZHANG
;
Zhengsheng LIU
- Publication Type:Journal Article
- Keywords:
surgical flap;
glucose;
lactic acid;
metabolism
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Bi-polar,bi-pedicled separation delayed flaps were designed on the backs of New Zealand rabbits with the application of a medical silicon membrane as the separation material. Values of glucose and lactic acid, PtcO 2 were measured separately at proximal,middle and distal areas of the flaps after the distal pedice was cut at 0,1,4,7,14,21 days,respectively, after the formation of flaps. After flap delaying,PtcO 2 in separated flap was always lower than that of the mormal control,accompanied with glucose decrease and lactic acid increase, although there were significant differences in different areas of the flap. The survived area of the flap increased after 7 days. Furthermore,all the length of the flap survived after 21 days,although the level of glucose in the flap was still lower and lactic acid was still higher.The results suggested that by separation and delaying the flap may adapt gradually to hypoxia via lowered metabolism.For flap survival,the threshold value of glucose in flap is 0 01mmol/L , lactic acid is 0 47mmol/L,and PtcO 2 is 3mmHg .
