Preliminary study of the value of clinical applications of superparamagnetic iron oxide in diagnosing small lesions of liver
- VernacularTitle:超顺磁性氧化铁诊断肝脏小病灶的临床应用价值初探
- Author:
Biao HUANG
;
Changhong LIANG
;
Hui ZENG
- Publication Type:Journal Article
- Keywords:
Contrast media;
Liver neoplasms;
Magnetic resonance imaging;
Comparative study
- From:
Chinese Journal of Radiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of Feridex in demonstrating small focal lesions of the liver on MRI and to discuss the optimal scan time after intravenous administration of Feridex. Methods Small focal lesions in the liver were found on ultrasound or CT in 17 patients. Conventional MR plain scan and Gd-DTPA enhanced scan were performed. One to three days later, T 2 weighted imaging was repeated at 0.5 h, 3 h, and 6 h after Feridex was administered intravenously over 30-40 min at a dose of 0.05 ml/kg. The pre- and post-contrast T 2WI were compared and analyzed in terms of lesion detectability and signal change. Results Twenty-one lesions with diameter smaller than 1 cm were found on the Feridex enhanced images, and only 8 lesions were found on the conventional MR images. The small hepatic cancers, focal nodular hyperplasia (FNH), and regenerated nodules had different signal changes on the Feridex images, which made the differential diagnoses easier. The signal of the liver decreased significantly (P0.05). Conclusion Fridex enhanced MR images could not only improve the detection of small focal lesions, but also provide evidence for differential diagnoses.
