STUDY OF IL-12 EXPRESSION IN THE PATHOGENESIS OF ACUTE GRAFT-VERSUS-HOST DISEASE
- VernacularTitle:IL1-2在急性移植物抗宿主病发病机制中的作用研究
- Author:
Xiaoping JU
;
Jianmin WANG
;
Fengla HAN
- Publication Type:Journal Article
- Keywords:
allogeneic hematopoietic stem cell transplantation;
interleukin 12;
acute graft versus host disease
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the potential role of interleukin 12 (IL 12) in human acute graft versus host disease (aGVHD). 26 patients undergoing allogeneic hematopoietic stem cell transplantation (allo HSCT) were included in this study. IL 12 protein and gene expression in peripheral blood mononuclear cells were measured using enzyme linked immunosorbent assay (ELISA)and reverse transcription polymerase chain reaction (RT PCR), respectively. The results showed that all the patients achieved engraftment.Among them, 10 patients developed grade ⅠGVHD, 5 patients deveolped grade Ⅲ or Ⅳ GVHD. IL 12 protein and gene expressions in peripheral blood mononuclear cells were significantly higher in patients with aGVHD compared with those without aGVHD.The levels of IL 12 correlated significantly with the severity of aGVHD .The results suggested that IL 12 might play an important role in the development of human aGVHD.
