EFFECT OF MENOPAUSE ON CHEMOKINE RECEPTOR CXCR2 ON HUMAN MONOCYTE
- VernacularTitle:绝经对人单核细胞趋化因子受体CXCR2的影响
- Author:
Zhubin LEI
;
Jianping LIU
;
Mi WEI
- Publication Type:Journal Article
- Keywords:
menopause;
estrogens;
monocytes;
receptors,CXCR2;
coronary disease
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effect of menopause on chemokine receptor CXCR2 expression on monocyte, 21 postmenopausal and 20 premenopausal women were enrolled in the present study. Fasting venous blood was collected, and plasma estrogen levels were determined with radio immunoassay. Monocytes were separated from peripheral blood with gelatin method. Protein expression of chemokine receptor was assayed with flow cytometry and mRNA concentration was measured with RT PCR. The results showed that the levels of plasma estrogen decreased, whereas protein and mRNA expression of chemokine receptor CXCR2 increased after menopause. The plasma estrogen levels were negatively correlated with chemokine receptor CXCR2 expression in monocytes. These data suggested that the changes in CXCR2 on monocytes might contribute to,at least partially,the increased risk of developing coronary heart disease associated with estrogen secretory changes.
