THE PRELIMINARY STUDY ON THE CHANGES IN THE EXPRESSION OF G PROTEINS ? SUBUNIT mRNA IN THYROID TUMOR
- VernacularTitle:甲状腺肿瘤G蛋白?亚基mRNA表达的初步研究
- Author:
Zhaohui LU
;
Guochun LUO
;
Changy PAN
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms;
heterotrimeric GTP binding proteins;
gene expression
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the changes in the expression of G proteins ? subunit mRNA in non functioning thyroid adenoma (NFTA) and thyroid papillary cancer (TPC). Eleven thyroid specimens were obtained during surgery, 6 of which from patients with NFTA and 5 from patients with TPC. The expression levels of stimulating and inhibiting G protein ? subunit mRNAs were determined by reverse transcription polymerase chain reaction (RT PCR). The expression levels of Gsa mRNA in TPCs were significantly higher than those in normal thyroids and NFTAs( P
