EFFECTS OF INTERMITTENT OVERPRESSURE IN EAR CANAL ON ENDOLYMPHATIC HYDROPS IN GUINEA PIGS
- VernacularTitle:豚鼠外耳道加压对实验性膜迷路积水的影响
- Author:
Zhiyong XU
;
Zhaohua LIU
- Publication Type:Journal Article
- Keywords:
ear canal;
pressure;
atrial natriuretic factor;
evoked potentials,auditory;
endolymphatic hydrops
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Intermittent overpressure of 20cmH 2 O was delivered to the external ear canal of guinea pigs. Histopathological changes in the middle and inner ear were examined under light microscope. Auditory evoked potential was recorded. The expression of atrial natriuretic peptide (ANP) was investigated by immunohistochemical SP method. We found that intermittent overpressure could minimize, but could not interrupt the development of endolymphatic hydrops,and could not improve hearing function. Expression of ANP decreased in the cochlear lateral wall after 2 week intermittent overpressure. The results suggested that intermittent overpressure of 20cmH 2 O was suitable in this experiment, and that ANP positive cells had an autocrine/paracrine function.
