THE EFFECTS OF COMPOUND ANTI-TUMOR GRANULES ON GROWTH INHIBITION AND EXPRESSION OF p53 AND PCNA IN MICE BEARING SARCOMA 180
- VernacularTitle:复方抗瘤冲剂抑制小鼠肉瘤180的生长及对p53和增殖细胞核抗原表达的影响
- Author:
Qingyong CHEN
;
Yuquan WU
;
Yongshen HE
- Publication Type:Journal Article
- Keywords:
compound antitumor granules;
antitumor effect;
proliferating cell nuclear antigen;
genes, p53;
sarcoma 180
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the anti tumor effect of "Compound" granules on mice bearing sarcoma 180 and its possible mechanism, We observed the effect of "Compound" granules on tumor weight and expression of p53 and PCNA in mice bearing sarcoma 180 by means of immunohisto chemistry. After treatment with "Compound" anti tumor granules, anti tumor granules (Ⅰ,Ⅱ,Ⅲ) and CTX, the results showed that "Compound" granules and the other four drugs could inhibit sarcoma 180 growth to various extent, and the rates of inhibition were 20 31%, 6 56%, 15 0%, 19 06% and 30 3%, respectively. Meanwhile,we found the expression of p53 and PCNA in mice bearing sarcoma 180 was affected in various groups.It suggested that compound anti tumor granules had antitumor effect and its possible mechanism might be associated with inhibition the expression of mutate p53 and PCNA.
