THE EXPRESSION IN SITU OF TELOMERASE RNA AND THE PROGNOSIS OF BLADDER TRANSITIONAL CELL CARCINOMA
- VernacularTitle:膀胱癌中端粒酶RNA的原位表达与肿瘤预后
- Author:
Yu HAN
;
Baofa HONG
;
Yon YANG
- Publication Type:Journal Article
- Keywords:
bladder neoplasms;
human telomerase RNA;
prognosis;
telomerase reverse transcript
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the expression of human telomerase RNA(hTR) in different grades of bladder transitional cell carcinoma and its relation to its prognosis. With in situ hybridization, the expression of hTR was observed in 67 cases of bladder transitional cell carcinoma specimens, to be compared with specimens of 10 normal bladder tissue and 10 benign lesions. The RNA probe used in hybridization was telomerase reverse transcript (TERT), and the marker was digoxin. There was a significent correlation between the expression of hTR and grading and prognosis. hTR is considered as an important and independent prognostic factor in this carcinoma.
