Clinical study on opioid polypeptides involved in epidemic encephalitis-B pathogenesis.
- VernacularTitle:阿片多肽参与流行性乙型脑炎发病机制的临床研究
- Author:
Chuande ZHUGE
;
Lin DENG
;
Xisheng QIU
- Publication Type:Journal Article
- Keywords:
Epidemic encephalitis-B Naloxone Opioid polypeptides Leucine-enkephalin ?-Endophin Dynorphin
- From:
Chinese Journal of Practical Internal Medicine
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives In order to study the endogenous opioid polypeptides involved in pathogenesis of epidemic encephalitis-B and the clinical therapeutic efficacy.Methods ①Leucine-enkephalin,?-endophin and Dynorphin levels in plasma and and CSF of patients with epidemic encephalitis-B during critical stage and convalescent stage were measured by radio-immunoassay.②Naloxone therapeutic efficacy in patients with epidemic encephalitis-B were investigated.Results Opioid polypeptides levels In plasma and CSF were significantly higher in critical stage and dropped to normal levels in convalescent stage.③We demonstrated that endogenous opioid polypeptides special antagnoist agent-Naloxone was a very important therapy agent for epidemic encephalitis-B patients.Therapy group efficacy was significantly better than control group.Conclusions These results demonstrate that endogenous opioid polypeptides involves in the physiopathologic changes of epidemic encephalitis-B.
