Effects of losartan on apoptosis and expression of Fas and Fas-L in the kidney of diabetic rats
- VernacularTitle:洛沙坦对糖尿病大鼠肾脏细胞凋亡及Fas和Fas-L表达的影响
- Author:
Yanling ZHANG
;
Huijun DUAN
;
Ying LI
- Publication Type:Journal Article
- Keywords:
Angiotensin II type 1 receptor antagonist;
Diabetic nephropathy;
Apoptosis;
Fas;
Fas-L
- From:
Chinese Journal of Nephrology
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of angiotensin II type I receptor antagonist losartan on apoptosis and the expression of Fas and Fas-L in the kidney of diabetic rats. Methods Uninephrectomized, STZ(65 mg/kg) -induced diabetic male SD rats were used. Losartan(40 mg/kg) was delivered daily by gavage from the next day of the induction to diabetes for 12 weeks. Apoptosis was examined by means of terminal-deoxynucleotidyl transferase mediated d-UTP nick end labeling(TUNEL) . Flow cytometry and immunohistochemistry were used to detect the expression of Fas and Fas-L. Results Compared with those in the kidneys of control group, apoptotic cells were more in number and the expression of Fas and Fas-L was higher in the diabetic kidneys( P
