THE EFFECT OF PROPOFOL ON THE CONTENT OF ENDOTHELIN AND CALCITONIN GENE-RELATED PEPTIDE IN THE MONKEYS WITH HEMORRHAGIC SHOCK AND RESUSCITATION
- VernacularTitle:异丙酚对猕猴失血性休克复苏血浆内皮素和降钙素基因相关肽的影响
- Author:
Mingjun WANG
;
Sujuan CHEN
;
Qin SONG
- Publication Type:Journal Article
- Keywords:
propofol;
shock,hemorrhagic;
endothelins;
calcitonin gene related peptide
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effect of propofol on the plasma contents of endothelin(ET) and calcitonin gene related peptide(CGRP).Twelve monkeys with hemorrhagic shock were divided randomly into two groups.The monkeys in propofol group(PG) were administered propofol to 8mg/L plasma concentration by target control infusion with computer,while monkeys in control group(CG) were not .Venous blood were collected to determine plasma ET and CGRP contents by radioimmunoassay before bleeding, 2 hours after hemorrhagic shock and 2h after resuscitation. Compared with control group,the CGRP level and CGRP/ET of PG were significantly increased at 2h after hemorrhagic shock and 2h after resuscitation,while ET level of PG at 2h after resuscitation was significantly lower than that of CG. These findings indicate that propofol can increase the plasma content of CGRP and decrease the plasma content of ET in monkeys after hemorrhagic shock and resuscitation, and ET may play an important role in the development of hemorrhagic shock.
