EFFECT OF UROKINASE ON PLATELET ACTIVATION AND AGGREGATION IN THE PATIENTS WITH GLOMERULONEPHRITIS
- VernacularTitle:尿激酶对肾小球肾炎患者血小板活化及凝集功能的影响
- Author:
Hongxiang LI
;
Jiyun ZHANG
;
Qiuhua LI
- Publication Type:Journal Article
- Keywords:
urinary plasminogen activator;
glomerulonephritis;
platelet activation;
platelet aggregation
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of urokinase on platelet activation and aggregation in the patients with glomerulonephritis. Platelet counts(PC),mean platelet volume (MPV), and platelet distribution width (PDW) were determined with automatic blood cell analytic apparatus, the expressive levels of platelet granular membrane protein (GMP 140) and fibrinogen receptor(GPⅡb Ⅲa) on the surfaces of platelets were assayed with flow cytometry, and the levels of fibinogen and fibrin degradation products (FDP) in blood were measured with ELISA in 102 children with glomerulonephritis. The results showed that urokinase led to PC decreas,MPV increase and PDW exceeding normal value in 102 children with glomerulonephritis, including micro change (MC),glomerulosclerosis (GS),membranous nephropathy (MN), and proliferative glomerulonephritis (PGN).The expressive levels of GMP 140 after the treatment with urokinase were significantly higher than that before the treatment and controls( P 0 01). The results suggested that urokinase used in the patients with glomerulonephritis increased platelet activation function and decreased platelet aggregation function.
