THE INHIBITORY EFFECT OF OCTREOTIDE ON THE PROLIFERATION AND EXPRESSION OF ENDOGENOUS GF-I IN VSMCs
- VernacularTitle:奥曲肽抑制血管平滑肌细胞增殖及内源性IGF-I的表达
- Author:
Lei DONG
;
Zaiping JING
;
Guison CAO
- Publication Type:Journal Article
- Keywords:
octreotide;
insulin like growth factor Ⅰ;
vascular smooth muscle cells
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of octreotide on DNA synthesis and the expression of endogenous insulin like growth factor I(IGF I)in newborn calf vascular smooth muscle cells(VSMCs) in vitro were analysed with 3 H thymidine incorporation and immunocytochemistry respectively.Concentration over 1 nmol/L of octreotide inhibited the increasing of 3 H thymidine incorporation induced by serum and IGF I in VSMCs. Serum and IGF I could stimulate the synthesis of endogenous IGF I in VSMCs.When cultured with 10 nmol/L of octreotide,the gray value of IGF I rose 16 0% and 13 3% respectively.It is suggested that octreotide can inhibit DNA synthesis induced by serum and IGF I in VSMCs,and the expression of endogenous IGF I in VSMCs.
