THE ROLE OF ELASTIN IN EXPERIMENTAL ANIMAL MODEL OF ABDOMINAL AORTIC ANEURYSM
- VernacularTitle:弹力蛋白在腹主动脉瘤发病中的作用
- Author:
Xiang FENG
;
Zaiping JING
;
Ju ZHAO
- Publication Type:Journal Article
- Keywords:
aortic aneurysm, abdominal;
elastin;
pathogenisis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship between the diameter of abdominal aortic aneurysm(AAA) and the concentration of elastin, forty five healthy male Wistar rats were selected,5 rats of them were used as normal control, the other 40 rats were randomly divided into 2 groups. A 1 cm segment of the abdominal aorta of the rat was isolated and perfused with pancreatic elastase in the experimental group, and the control group was given normal saline solution. Laparotomy was performed immediately after operation and on the 2, 7, 14 day, the aortas were measured and harvested. Histological studies were carried out to analyze the changes in elastin. The aortic diameter progressed to aneurysmal dimension in the experimental group. Histological study revealed loss of elastin in tunica media of the aorta in the experimental group. Neither macroscopic nor microscopic lesions were found in control group. It is suggested that there is a significant correlation between the aortic diameter and the decreased elastin content.
