Effect of neural cell adhesion molecule on growth of human malignant glioma cellsin vivo and in vitro
- VernacularTitle:神经细胞粘附分子对人恶性脑胶质瘤细胞株体内外增殖能力的影响
- Author:
Jianjun WANG
;
Li GAO
;
Zhi ZHU
;
Li LI
- Publication Type:Journal Article
- Keywords:
cell adhesion molecules,neuronal;
transfection;
prolifera tion;
glioma
- From:
Academic Journal of Second Military Medical University
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: : To investigate the influence of neura l cell adhesion molecule(NCAM) on the proliferative behavior of human U251MG cell line. Methods: After transfecting with human transmembrane 140- kDa isoform of NCAM. The alteration of cell cycle, growth rate of cell populatio n of human U251MG and G251 line in vitro , and the tumor growth rate, tumor s ize of intracerebral tumors in nude mice were all compared. Results: It revealed in the NCAM-transfected cell line a lower proliferation rate ( P
