The Effect of Topical Dapiprazole on Phenylephrine and Tropicamide-induced Mydriasis.
- Author:
Chung Seong LEE
1
;
Nam Cheol JI
Author Information
1. Department of Ophthalmology, Chosun University Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Alpha-adrenergic blocker;
Dapiprazole;
Reversal of mydriasis
- MeSH:
Dilatation;
Humans;
Mydriasis*;
Phenylephrine*;
Pupil;
Tropicamide
- From:Journal of the Korean Ophthalmological Society
1993;34(12):1269-1274
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to evaluate the effect of topical dapiprazole, an alpha-adrenergic receptor blocker, in reversing mydrisis by 1% tropicamide and 2.5% phenylephrine, we studied 89 subjects. 0.5% dapiprazole in one eye of each subject after full dilatation of both pupils. The pupillary diameter was calibrated, and thereafter statistical analysis was performed with student paired t-test. Thirty minutes after instillation of dapiprazole, there was a highly significant difference of the decreasing rate in pupil size between the dapiprazole treated eyes and the control eyes(p<0.001). The time for complete reversal of mydriasis was also at least 4 hours shorter in the dapiprazole treated eyes than the control eyes(p<0.006). This study suggests that 0.5% dapiprazole is effective in reversing mydriasis caused by 1% tropicamide and 2.5% phenylephrine, and also effective in making the eyes comfortable in a shorter time.
