STUDY OF TWO-PEAK FEATURE OF c-fos EXPRESSION IN NEURONS AFTER SEVERE BRAIN INJURY AND ITS MECHANISM IN MICE
- VernacularTitle:重型颅脑损伤后神经元细胞c-fos基因表达的双峰特征及机制研究
- Author:
Zhanxiang WANG
;
Xiang ZHANG
;
Zho FEI
- Publication Type:Journal Article
- Keywords:
craniocerebral trauma;
gene, fos;
neurons
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the time dependent features and mechanisms of c fos expression in neurons after brain injury in mice. Using the mice model of severe traumatic brain injury, c fos expression in neurons was observed at different time points after trauma with the molecular hybridization and immunohistochemistry staining. A c fos expression process in neurons occurred after severe brain injury, peaking at 1 hour. Another expression peak appeared 24 hours later. Fos positive neurons were observed in the cerebral cortex of injured hemisphere, especially in Ⅱ Ⅳ layers. The c fos gene expression after brain injury in neuron has two peaks. c fos gene expression may be caused by Leao’s spreading depression, and may be associated with cell signal transduction and neuron apoptosis.
