MONITORING ACUTE REJECTION OF PANCREAS ALLOGRAFT TRANSPLANT
- VernacularTitle:胰腺移植急性排斥反应的监测
- Author:
Weisu LI
;
Kai LUO
;
Qunl SHI
- Publication Type:Journal Article
- Keywords:
pancreaticoduodenal transplantation;
acute rejection;
diagnosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the monitoring of acute rejection of porcine pancreaticoduodenal allografts, 12 pigs were subjected to pancreaticodudenal allografts, among them 6 pigs received triple therapy for 7 days. Serial biopsies were performed in pancreas allografts for diagnosis of pancreatic acute rejection. Amylase secretion was determined periodically.The levels of TNF ? and NO in serum were serially monitored.The results showed that amylase secretion decreased,TNF ? and NO concentration in serum increased significantly as acute rejection was detected histo pathologically in pancreatic grafts. It suggested that monitoring of amylase secretion, serum TNF ? and NO concentration could be used to decide the proper time of performing biopsy for early diagnosis of acute rejection of the pancreas allograft.
