THE QUANTITATIVE ANALYSIS OF THE EXPRESSIONS OF MATRIX METALLOPROTEINASES AND TISSUE INHIBITOR OF METALLOPROTEINASE IN COLORECTAL CANCER
- VernacularTitle:基质金属蛋白酶及其抑制物在大肠癌表达的定量分析
- Author:
Xiangjun CAI
;
Jing ZHOU
;
Qingchan LI
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
matrix metalloproteinases;
neoplasms metastasis;
prognosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship of the expressions of matrix metalloproteinases(MMPs) and tissue inhibitor of metalloproteinase (TIMP) with metastasis and prognosis in colorectal cancer. Using S P immunohistochemistry method to detect the expressions of MMPs and TIMP in 41 cases of colorectal cancer. The expression levels were analyzed quantitatively by computer image analysis system. The results showed that the expression of MMP 2,MMp 9 and TIMP 1 was higher than those in normal epithelial mucosa. In the cases with metastasis to lymph node, the expressions of MMP 2 and MMP 9 TIMP 1 were significantly higher than that of cases without metastasis.The high expressions of the three factors are closely correlated with the progression and poor prognosis of colorectal cancer. It suggested that expressions of MMPs and TIMP are closely related with metastasis and prognosis in colorectal cancer.
