THE PROTECTIVE EFFECT OF TAKEPRON ON THE GASTRIC MUCOSAL LESION IN RATS AND ITS MECHANISMS
- VernacularTitle:达克普隆对胃粘膜损伤保护作用及其机制
- Author:
Qiaoliang LE
;
Jie ZHANG
;
Qizhen XU
- Publication Type:Journal Article
- Keywords:
takepron;
gastric mucosal lesion;
cytoprotection;
nitric oxide
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the protective effect of takepron(lansoprazole)on the gastric mucosal lesion in rats and its mechanisms . Before gastric mucosal lesion was produced in rats with pure alcohol,takepron was administered into the gastric lumen, and N? nitro L arginine methyl ester(L NAME) and L arginine were injected intravenously. Gastric mucosal blood flow(GMBF)was assessed with laser Doppler flowmetry,gastric mucosal and serum NO - 2 /NO - 3 were measured by cadmium granulation reduction and colorimetric method,and the gastric mucosal ulcer index(UI),the degree of tissue necrosis and neutrophil infiltration were observed . The results showed that UI of the takepron group was much lower than that of the control group( P
