THE CLINICAL SIGNIFICANCE OF HIGH EXPRESSION OF CD40L IN PATIENTS WITH ACUTE CORONARY SYNDROMES
- VernacularTitle:CD40L高表达在急性冠脉综合征病人中的临床意义
- Author:
Jinchuan YAN
;
Zonggui WU
;
Zu HUANG
- Publication Type:Journal Article
- Keywords:
CD40 ligand;
acute coronary syndromes;
atherosclerosis;
angina pectoris
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the clinical significance of the expression of CD40L on peripheral blood monocytes and the changes in serum soluble CD40L in patients with acute coronary syndrome, 16 normal controls and fifty-six patients including 24 with SA (8 patients after PTCA), 20 with UA and 12 with AMI entered in this study. The expression of CD40L on monocytes was analyzed by indirect immonofluorescence flow cytometry and serum sCD40L levels were measured by ELISA. The results showed: (1) The expression of CD40L on monocytes in UA and AMI were higher compared with SA and controls ( P 0.05). (2) Patients with UA and AMI had significantly raised serum levels of sCD40L when compared with patients with SA and controls( P
