ANALYSIS OF X GENE MUTATIONS IN HEPATITIS B VIRUS GENOME POSITIVE FOR ANTI-HBE BETWEEN ASYMPTOMATIC CARRIER AND PATIENTS WITH CHRONIC ACTIVE HEPATITIS
- VernacularTitle:HBe抗体阳性的乙型肝炎活动与静息HBV X基因变异的对比研究
- Author:
Jie PENG
;
Kangxian LUO
;
Jinli HOU
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
X gene mutation;
asymptomatic carrier;
hepatitis,chronic
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To elucidate whether the mutations in X region of hepatitis B virus (HBV) might be responsible for the different clinical profiles in cases positive for antibody to hepatitis B e antigen. The nucleotide sequences of X gene regions in serum HBV were examined in 14 asymptomatic carriers (AsC) and 14 chronic active hepatitis (CAH) patients with antibody to hepatitis e antigen. The results showed that 12 of 14 AsCs (85.7%) had insertions, deletions or point mutations in nucleotide sequence of X region resulting in truncation of the X protein by creating frame shift mutation or a new stop codon, whereas no patient with CAH had those X gene mutations( P
