COMPARATIVE STUDY ON PHARMACOKINETICS OF 5-FU INJECTED VIA SPLENIC ARTERY AND AURICULAR VEIN IN RABBITS
- VernacularTitle:兔脾动脉插管和耳静脉穿刺灌注氟尿嘧啶门静脉检测的药代动力学研究
- Author:
Xiaohua ZENG
;
Songzhang WANG
;
Xiaochu WU
- Publication Type:Journal Article
- Keywords:
fluorouracil;
pharmacokinetics;
rabbits
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the pharmacokinetics of 5 FU after splenic artery(IA) and auricular vein(IV) infusion, portal vein blood was collected for measurement to appraise the clinical value of treatment with this anti tumor drug via different routes on malignant hepatic neoplasms. 5 FU in portal vein blood was measured with high performance liquid chromatography. The results showed that the concentration of 5 FU in IA group was higher than that in the IV group. The peak concentration of 5 FU in the IA group was higher than that in the IV group by 64%. The area under the curve (AUC) of 5 FU in the IA group was larger than that in the IV group by 42%. It suggested that higher concentration of anti tumor drug in the portal vein could be obtained via splenic artery infusion, and it is valuable for the treatment of malignant hepatic neoplasms.
