INHIBITING EFFECTS OF BENAZEPRIL AND LOSARTAN ON MYOCARDIAL MITOGENIC ACTIVATED PROTEIN KINASE
- VernacularTitle:芦沙坦和苯那普利对心肌丝裂素活化蛋白激酶的抑制作用
- Author:
Liping ZHANG
;
Qiupu ZHENG
;
Kunlu HE
- Publication Type:Journal Article
- Keywords:
mitogen activated protein kinase;
cardiac hypertrophy;
agiotensin Ⅱ
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
SHRs were randomly divided into three groups: SHRs control group, Benazepril group (10mg/kg?d) and Losartan group (30mg/kg?d). WKYrats act as the normal control group. The animals were treated for 3 months. Compared with WKY rats, the blood pressure, angiotensinⅡ(AⅡ)levels in blood and myocardium, mitogen activated protein kinase (MAPK) activity, and myocardial hypertrophy in SHRs control group were increased ( P
