EFFICACY OF LAMIVUDINE IN PATIENTS WITH HEPATITIS B VIRUS REINFECTION AFTER LIVER TRANSPLANTATION
- VernacularTitle:拉米夫定预防肝移植术后乙型肝炎病毒再感染的研究
- Author:
Changhong CHEN
;
Jiahong DONG
;
Shuguan WANG
- Publication Type:Journal Article
- Keywords:
lamivudine;
liver transplantation;
hepatitis B virus;
superinfection
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the therapeutic effect of Lamivudine on reinfection of hepatitis B virus, seven patients with terminal HBV related hepatic diseases who had received orthotopic liver transplantation, were studied. Among them, 5 patients were treated with lamivudine bcfore and after liver transplantation, and 2 patients received common antiviral treatment. No hepatitis B virus reinfection and YMDD mutations occurred in the group of patients with Lamivudine therapy. However in the group of patients receiving common antiviral therapy, both patients suffered from hepatitis B virus reinfection. Lamivudine is potentially effective in the prophylaxis of hepatitis B virus reinfection after orthotopic liver transplantation.
