The expression of TGF ? receptor Ⅰ and apoptosis in gastric carcinoma and precancerous lesions.
- VernacularTitle:胃癌及癌前病变组织中转化生长因子?Ⅰ型受体的表达与细胞凋亡
- Author:
Zehao ZHUANG
;
Yuli CHEN
;
Chengdang WANG
- Publication Type:Journal Article
- Keywords:
Receptor\ Transforming growth factor beta\ Apoptosis\ Precancerous conditions\ Stomach neoplasms
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of TGF ? receptor Ⅰ(RⅠ)and apoptosis in gastric carcinoma and precancerous lesions,and their effects in the development of gastric carcinoma.Methods The expressions of TGF ?RⅠ in 103 cases,including CSG(30 cases),IM(30 cases),Dys(18 cases)and GAC(25 cases)were detected by immunohistochemical techniques(SP),apoptosis cells were examined by terminal deoxynucleotidyl transferase(TdT) mediated dUTP nick end labelling(TUNEL).Results Both the expressions of TGF ?RⅠ and apoptosis indexes(AI:percentage of TUNEL positive cells)showed negative correlation with the degree of gastric mucosa lesions from CSG,IM,Dys to GAC(r=-0\^7272,P
