Studies on mouse hyperuricemia model
- VernacularTitle:小鼠高尿酸血症模型的研究
- Author:
Guangliang CHEN
- Publication Type:Journal Article
- Keywords:
animaldisease model;
hyperuricemia;
uric acid;
mouse
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To establish hyperuricemia animal model. METHODS The mice were given uric acid by ip and then the level of uric acid in serum was detected. RESULTS Uric acid 125,250,500, 1 000 mg?kg -1 ip significantly increased the level of uric acid in mouse serum. The level of uric acid in mouse serum was attained peak at 10 min and the hyperuricemia could lasted over 4 hours after uric acid 250 mg?kg -1 given. CONCLUSION Uric acid given by ip can form mouse hyperuricemia model, the dosage of 250 mg?kg -1 is better.
