The therapeutic efficacy of recombinant interferon alfa-1b for the treatment of chronic hepatitis B and its predictive factors
- VernacularTitle:干扰素?-1b治疗慢性乙型肝炎的疗效及其预测因素分析
- Author:
Weimin MA
;
Jian LU
;
Xiaoling JIANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B chronic;
Interferon ? 1b;
Antiviral agents;
Predictive factor
- From:
Chinese Journal of Infectious Diseases
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the short term and long term response and the safety of the different doses of recombinant interferon alfa 1b(IFN? 1b) for the treatment of the patients with chronic hepatitis B and the predictive factors of the response. Methods 146 Chinese patients with chronic hepatitis B entered randomly into four groups. Three groups were given with IFN ? 1b 3 million unit (MU), 5 MU and 10 MU respectively. The control group was given placebo. The short term(ETR) and long term(SR 12) responses and side effect were observed. Selected nineteen items (host related, drugs related and virus related), which affected the response of IFN alfa 1b probably (host, virus and drugs, et al) were analyzed. Results The end treatment response (ETR) of the IFN ? 1b 5 MU therapy was 55.3%, and 10 MU was 58.1%. Both efficacy were higher than the group of 3 MU IFN alfa 1b (32.6%) and control therapy group (5.9%, P
