THE CHANGES IN DENSITY OF PLATELET GLYCOPROTEIN(GP)Ⅱb/Ⅲa RECEPTOR DURING THE PERIOPERATIVE PERIOD OF HEPATECTOMY IN RATS WITH MYOCARDIAL INFARCTION
- VernacularTitle:心肌梗死大鼠肝叶切除围手术期血小板表面Ⅱb/Ⅲa受体的变化
- Author:
Yufeng LI
;
Shiwen WANG
;
Jingmi ZHAO
- Publication Type:Journal Article
- Keywords:
perioperative period;
rats;
myocardial infarction;
platelet membrane glycoproteins;
hepatectomy
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate changes in density of platelet glycoprotein (GP)Ⅱb/Ⅲa receptor during the perioperative period of hepatectomy in rats with myocardial infarction. 26 adult SD rats were randomly divided into 2 groups: the control group(1)( n =13) and the infarction group(2)( n =13). Myocardial infarction was produced by celiac injection (1 time/d) of isoproterenol (30mg/kg) for 3 days. All rats underwent hepatectomy after 3 weeks. Platelet surface density of GPⅡb/Ⅲ receptors was determined by flow cytometric analysis before and 6, 12, 24, 48, 72 hours after the operation. 12 hours after the operation, the density of GPⅡb/Ⅲa was transiently increased compared with preoperative period in control group ( P
