THE STUDY OF MEMBRANE TYPE 1 MATRIX METALLOPROTEINASE (MT 1 MMP) EXPRESSION IN THE PROCESSES OF EXPERIMENTAL LIVER FIBROSIS AND ITS REVERSAL
- VernacularTitle:实验性肝纤维化形成及逆转过程中膜性基质金属蛋白酶1mRNA表达的动态研究
- Author:
Shaoli YOU
;
Jingmin ZHAO
;
Shaoji XIN
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinases;
liver fibrosis;
gene expression
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate MT 1 MMP mRNA expression in the development of liver fibrosis and during the reversal of liver fibrosis ,we undertook a dynamic observation by situ hybridization. Liver fibrosis model was established by intraperitoneal injection with CCl 4 in Wistar rats, then allowed them fo recover spontaneously to observe the reversal of liver fibrosis .The results showed that MT 1 MMP mRNA was expressed mainly in mesenchymal cells(such as hepatic stellate cell), also in a part of hepatocytes.The levels of MT 1 MMP mRNA expression were increased gradually in the development of liver fibrosis and decreased gradually during reversal of liver fibrosis. These results suggest that the expression of MT 1 MMP may have an important role in the development of liver fibrosis and its reversal.
