ESTABLISHMENT OF A RAT MODEL OF MIDDLE CEREBRAL ARTERY THROMBOTIC ISCHEMIA
- VernacularTitle:大鼠大脑中动脉血栓形成模型的建立
- Author:
Zhaoyan ZHANG
;
Shusu GUO
;
Xi CAO
- Publication Type:Journal Article
- Keywords:
middle cerebral artery;
thrombosis;
rat
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
A catheter(0.3 mm O.D.)was introduced into the external carotid artery(ECA) lumen into the lumen of the internal carotid artery(ICA), then it was gently advanced to the intracranial segment of ICA until the intraluminal catheter was 2~3mm from the origin of MCA. At this point thrombin were injected into ICA to induce thrombosis. Behavior disorders were observed at 3, 6, 12h after the operation. Willis circle, infarct volume and histopathologic changes were examined 12 hours after operation. The results showed that the model had stable behavior disorder score and infarct volume. Mixed thrombus could be observed at the origin of the MCA. Infarction volume of this model was similar with that of the model developed by linear occlusion of MCA in our laboratory. The model has the advantages of easy operation, reliable ischemia and reproducible infarct volume. It may be useful in documenting the safety and efficacy of thrombolytic therapies.
