A STUDY ON THE MECHANISM OF BENAZIPRIL IN PREVENTING THE PROGERSSION OF GLOMERULOSCLEROSIS
- VernacularTitle:苯那普利防治肾小球硬化的实验研究
- Author:
Wenxin WANG
;
Xiangmei CHEN
;
Yizho YE
- Publication Type:Journal Article
- Keywords:
benazipril;
glomerulosclerosis;
gene, MMP 9, TIMP 1
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
nephrectomy in Wistar rats were used to replicate the animal model of focal and segmental glomerular sclerosis.Then a group of 5/6 nephrectomized rats were given Benzaipril for 20 weeks , in order to evaluate the effects of Benazipril on degradation of extracellular matrix. The results showed that Benzipril not only reduced renal pathological changes, but also significantly decreased the type Ⅳ collagen and MMP 9 deposition and down regulated the mRNA expressions of MMP 9 and TIMP 1 in the remnant kidneys of the 5/6 nephrectomized rats. It suggested that Benzipril might ameliorate glomerulosclerosis through the mechanism of modulating extracellular matrix degradation in the remnant kidney tissue.
