THE EFFECT OF HEPARIN AND LOW MOLECULAR WEIGHT HEPARIN ON THE RECEPTOR OF AGE ON HUMAN MONOCYTE SURFACE
- VernacularTitle:比较肝素和低分子量肝素对人单核细胞表面AGE受体的影响
- Author:
Hao REN
;
Fanfan HOU
;
Xun ZHANG
- Publication Type:Journal Article
- Keywords:
heparin;
heparin, low molecular weight;
monocytes;
glycosylation end products,advanced;
hemodialysis
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Radioactive ligand receptor binding assay was used to study the binding effect of heparin and low molecular weight heparin (LMWH) on the receptor of advanced glycation end products (AGE) on monocyte surface in normal individual and chronic renal failure (CRF) patients undergoing hemodialysis. The results showed that heparin caused a dose dependent inhibition of receptor binding to AGE, however LMWH did not have such inhibitory effects. The results suggest that heparin could interrupt AGE clearance and degradation, and LMWH had not these effects.
