STUDY ON THE EXPRESSION OF ICAM-1 AND TNF-? IN GASTRIC MUCOSAL CELL DURING DRUG INDUCED GASTRIC MUCOSAL INJURY IN RAT
- VernacularTitle:药物性胃粘膜损伤大鼠ICAM-1及TNF-?表达的研究
- Author:
Wei ZHANG
;
Benyan WU
;
Weidi YOU
- Publication Type:Journal Article
- Keywords:
gastric mucosal injury;
intercellular adhesion molecule 1;
tumor necrosis factor
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of ICAM 1 and TNF ? in gastric mucosal cell during drug induced mucosal injury, the authors carried out the study in SD rats with aspirin by mouth with immunohistochemical method . The results showed that ICAM 1 began to express at 30min after administration of aspirin, peaked at 1h, maintained until 6h, decreased at 12h,and expressed slightly at 24h . TNF ? began to express at 15min, peaked at 3h to 6h,decreased at 12h, and expressed significantly at 24h. There was a slight ICAM 1 and TNF ? expression in gastric mucosal cells in the control group. It was suggested that the expression of ICAM 1 and TNF ? plays an important role in the mechanisms of gastric mucosal injury .
