Effects of inducers of differentiation on telomerase activity in malignant cells
- VernacularTitle:细胞分化诱导剂与端粒酶活性调控
- Author:
Liming ZHANG
;
Qian HE
;
Guang YANG
;
Zhilong CHEN
- Publication Type:Journal Article
- Keywords:
telomerase;
cell differentiation;
retinoids;
vitamin fo compounds
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
More than 85% of all cancers express telomerase activity. Human telomerase has been proposed as a novel and potentially highly selective target for canon therapy. Inducers of differentiation are involved in regulation of telomerase activity. In the present review, the effects of retinoids, vitamin D3 compounds, tea catechins and matrine on telomerase activity in malignant cells were reviewed.
