Stimulating proliferation of aorta smooth muscle cells of rat by rat urotensin Ⅱ
- VernacularTitle:尾加压素Ⅱ对血管平滑肌细胞增殖的影响
- Author:
Yonggang ZHANG
;
Yongfen QI
;
Chunfang XIA
;
Yongzheng PANG
;
Jun YANG
;
Zhaokang ZHANG
;
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
urotensin Ⅱ;
proliferation;
mitogen
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate effect of urotensin Ⅱ (U Ⅱ )on proliferation of aorta smooth muscle cells (ASMC) of rat and study the signal transduction pathway of it. MEfHODS in cultured ASMC of rat, U Ⅱ was used to stimulate proliferation of these cells and levels of [3H]-TdR incorporation were used to evaluate the sped of DNA synthesis, and different inhibitors were ed to study the action of different signal transduction pathway of mitogenic effect of UⅡ on VSMC. RESULTS. 1 ? 10-9~l ? 10-7 mol. L-l U Ⅱ caused marked concentration-de pendent increasing of [3H]-TdR incorporation of ASMC [3H]-TdR incorporation of 1 ? 10-9, 1 ? 10-8 and １ ? 10-7 mol. L－l U Ⅱ were 22%'(P
