The effect of bFGF on the apoptosis and its relative gene in rat brain following cerbral ischemia-reperfusion
- VernacularTitle:bFGF对缺血性大鼠脑细胞凋亡及相关基因表达的影响
- Author:
Yuan FANG
;
Yu WANG
;
Etang TONG
;
Shenggang SUN
;
Yuanwu MEI
;
Guirong WEI
- Publication Type:Journal Article
- Keywords:
bFGF;
HSP 70;
p53;
apoptosis;
cerebral ischemia-reperfussion
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of exogenous bFGF on the cell apoptosis and the expression of HSP 70 protein and p53 gene. METHODS The effect of exogenous bFGF on HSP 70 protein and gene expression was examined vial insitu hybridization and immunohistochemistry, at 0-72 h reperfusion after the middle cerebral artery (MCA) was occluded for 2 h in rats. Simutaneously, the distribution of apoptosis was observed. RESULTS The expression of HSP 70 protein elevated and the expression of p53 gene and cell apoptosis decreased in bFGF treated rats as compared with ischemia rats. (P
