Protective effect of taurine on diaphragm against adriamycin cytotoxicity
- VernacularTitle:牛磺酸对阿霉素致膈肌毒性的保护作用
- Author:
Sudong GUAN
;
Min GE
- Publication Type:Journal Article
- Keywords:
taurine;
adriamycin;
diaphragm;
diaphragm evoked potential;
transdiaphramatical pressure;
MDA;
superoxide dismutase
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study protective effect of taurine on diaphragm against adriamycim cytotoxity in rabbits. METHODS The rabbits were divided randomly into three groups. groups group: The animals were administered NS 2 ml.kg- 1 for five days. ②Adriamycin + NS group: The animals were administered NS 2ml. kg-1 for five days and then administered adriamycin 10 mg. kg- 1. ③Adriamycin + taurine group: The animals were administered taurine 100 mg. kg-1 for five days and then administered adriamycin 10 mg?kg- 1. After 24 h, three groups animals were anaesthetized. The transdiaphragmatic pressure(Pdi) and diaphragm evoked potential(DEP) were measured. an and MDA were tested. the ultrastructure of diaphragm cells was investigated by eletronmicroscopy. RESULTS The Pdi and amplitude of DEP were lowered by adriamrcin(P
