INTRAMUSCULAR BONE FORMATION BY IMPLANTATION OF COMPOSITE MARROW STROMAL OSTEOBLAST-CANCELLOUS BONE MATRIX ARTIFICIAL BONE
- VernacularTitle:骨髓基质成骨细胞-松质骨基质复合人工骨肌袋移植的成骨作用
- Author:
Kai TAO
;
Tianqiu MAO
;
Weidong YANG
- Publication Type:Journal Article
- Keywords:
tissue engineering;
marrow stromal osteoblast;
cancellous bone matrix
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The marrow stromal cells of adult New Zealand rabbits cultivated and induced in vitro were used to form MCCAB by mixing,seeding and solidifying methods with the aid of alginate. The MCCABs were auto-transplanted intramuscularly into the rabbits for 4 to 8 weeks. The alginate-cancellous bone matrix composites or the cancellous bone matrix alone were implanted as control. The effectiveness of bone formation was assessed by means of roentgenography and histology.The results showed that the osteogeneses of MCCABs were better than those of the alginate-cancellous bone matrix composites and of the cancellous bone matrix. In the MCCABs, both intramembranous and cartilaginous osteogenesis were seen with the former predominating. In the control, only slight cartilaginous osteogenesis was seen. The results suggested that the osteogenesis of the MCCABs constructed by using tissue engineering method was obvious when transplanted intramuscularly, therefore, this kind of tissue-engineered bone could be an effective way for clinical application.
