INFLUENCE OF TUMOR MDR ASSOCIATED CMH ON THE EXPRESSION OF B7 IN DC
- VernacularTitle:肿瘤耐药相关鞘糖脂CMH对人树突状细胞B7表达的影响
- Author:
Jian ZHANG
;
Jiren ZHANG
;
Senming WANG
- Publication Type:Journal Article
- Keywords:
drug resistance, multiple;
neutral glycosphingolipids;
dendritic cells
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the role of tumor multidrug resistance (MDR) associated with CMH in the immunological evasion of MDR tumor cells, CMH was separated from neutral glycolipids of KBv 200by column chromatography, and the expression of B7 in DC was detected by flow cytometry. The results showed that the expression of B7 in DC was inhibited by CMH, it suggested the tumor MDR associated with glycolipids may inhibit human immune response by its effects on DC.
