THE EFFECT OF BIOPTERIN SYNTHESIS INHIBITOR ON ACUTE LUNG INJURY IN POSTBURN STAPHYLOCOCCUS AUREUS SEPSIS
- VernacularTitle:抑制生物蝶呤合成对大鼠烫伤后金葡菌感染所致肺损伤的影响
- Author:
Hongyun LI
;
Yongming YAO
;
Zhiguo SHI
- Publication Type:Journal Article
- Keywords:
burns;
Staphylococcus aureus;
biopterin;
nitric oxide;
sepsis
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
To determine the role of biopterin in acute lung injury in scald rats with infection, and to observe the therapeutic effect of GTP-cyclohydrolase I(GTP-CHI) inhibitor on postburn sepsis, 56 male Wistar rats were randomly divided into four groups: normal controls (n=10), scald control group(n=10), postburn sepsis group(n=20) and 2,4-diamino-6-hydroxy-pyrimidine (DAHP) treatment group (n=16). Tissue samples from lungs were collected to determine GTP-CHI and inducible nitric oxide synthase (iNOS) mRNA expression, meanwhile biopterin, nitric oxide (NO), tumor necrosis factor-?(TNF-?) and interferon-? (IFN-?) levels in lungs were also measured. The results showed that after scald injury followed by Staphylococcus aureus challenge, GTP-CHI gene expression and biopterin levels significantly elevated in lungs, so did the values of iNOS mRNA expression and NO induction (P
