THE INHIBITORY EFFECT OF DEXAMETHASONE ON THE EXPRESSION OF PKC IN THE LUNG,THE SPINAL GANGLIA AND THE SPINAL DORSAL HORNS OF THE ASTHMATIC GUINEA PIGS
- VernacularTitle:地塞米松对哮喘豚鼠肺内、脊神经节及脊髓背角内蛋白激酶C表达的抑制作用
- Author:
Deshou CAO
- Publication Type:Journal Article
- Keywords:
Protein kinase C;
Dexamethasone;
Lung;
Spinal ganglia;
Spinal dorsal horn;
Asthma;
Immunohistochemistry;
Western blotting;
Guinea pig
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the inhibitory effect of dexamethasone on the expression of protein kinase C(PKC) in the lung,the C-7-T-5 spinal ganglia and the corresponding spinal dorsal horns of the asthmatic guinea pigs. Methods The alterations of PKC immunoreactivity were investigated by means of immunohistochemistry and Western blot in the lung,the C-7-T-5 spinal ganglia and the corresponding spinal dorsal horns of the asthmatic guinea pigs.Results The average optic density of PKC in the lung,the C-7-T-5 spinal ganglia and the corresponding spinal dorsal horns of the asthmatic guinea pigs was much higher than that of the control group(P
