LOW-PROTEIN DIET AND KIDNEY FUNCTION IN NON-INSULIN-DEPENDENT DIABETIC NEPHROPATHY
- VernacularTitle:低蛋白饮食对老年糖尿病肾病肾功能的保护作用
- Author:
Ning ZHU
- Publication Type:Journal Article
- Keywords:
diabetic nephropathies;
renal failure,chronic;
diet,low-protein
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
This study tried to investigate the change in the glomerular filtration rate in initiation of a low-protein diet (LPD) in the elderly patients with diabetic nephropathy, and to elucidate whether this initial phenomenon is reversible or irreversible. 24 non-insulin-dependent diabetic patients with renal failure patients were randomized to LPDⅠgroup (0.6g ?kg -1?24h -1), LPDⅡgroup (0.8g?kg -1?24h -1), and NPD group for four weeks (phaseⅠ). Between weeks 4 and 8, all patients received NPS (phaseⅡ). Dietary protein intake (g?kg -1?24h -1), SCr, Ccr, albuminuria excretion rate and arterial blood pressure were measured at baseline and after four- and eight-weeks of follow-up, respectively. During phaseⅠ, a significant decline in dietary protein intake, Ccr, Scr, and albuminuria excretion rate were observed in the LPDⅠgroup and LPDⅡgroup. There was not any change in the NPD group. Conversely, during phase Ⅱ, with a significant increase in dietary protein intake, Ccr, Scr and albuminuria excretion rate increased in LPDⅠ group and LPD Ⅱ group compared with the NPD group. It suggested that dietary protein restriction for four weeks induces a reversible decline in GFR, Scr and albuminuria excretion rate in noinsulin-dependent diabetic nephropathy patients with renal failure, whereas systemic blood pressure remains unchanged.
