Relationship between the expression of B7-1 in liver tissue and the effect of interferon-alpha treatment in patients with chronic hepatitis B
- VernacularTitle:慢性乙型肝炎肝组织B7-1表达与?-干扰素近期疗效的关系
- Author:
Xingfeng REN
;
Kangxian LUO
;
Lian ZHANG
- Publication Type:Journal Article
- Keywords:
Viral hepatitis B7-1 Interferon
- From:
Chinese Journal of Practical Internal Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To evaluate the relationship between the expression of B7-1 in liver tissue and the effect of interferon-alpha(?-IFN) treatment in patients with chronic hepatitis B(CHB).Methods The expression of B7-1 in liver biopsy specimens from 68 CHB patients was studied with immunohistochemistry before ?-IFN treatment.Results B7-1 was expressed in 45(66 2%) liver tissues among 68 patients with CHB,but none in 5 normal controls.The total response ratio of ?-IFN in patients with B7-1 positive was 66 7%(30/45),which was significantly higher than 39 1%(9/23)in the patients with B7-1 negative (? 2=7 20,P
