INFLUENCE OF SEVOFLURANE ON BLOOD BRAIN BARRIER PERMEABILITY IN RATS
- VernacularTitle:七氟醚对成年大鼠血脑屏障通透性的影响
- Author:
Hong WANG
;
Yunqin SONG
;
Zhijia ZHANG
- Publication Type:Journal Article
- Keywords:
sevoflurane;
blood brain barrier;
permeability;
rat
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the influence of different concentrations of sevoflurane on blood brain barrier permeability in rats, thirty adult male SD rats were randomly divided into three groups: control group (without general anesthetics), 1 MAC sevoflurane and 1.5 MAC sevoflurane groups (maintaining end expiratory concentration to 2.2% and 3.3% respectively for 1 hour). Before the end of the experiment, 2% Evans′ blue dye (EB, 3ml/kg) was intravenously injected. The range and areas of EB staining on the surface and standardized serial coronal section of the brain were assessed. The brain was also observed under the light microscope and electron microscope. The results indicated that sevoflurane at both concentrations did not increase the permeability of BBB to EB and lanthanum, and there were no significant changes in morphological features of central nervous system after inhalation of sevoflurane.
