THE CHANGE IN mGluR1? IN CA_1 AFTER INFRASONIC DAMAGE AND THE EFFECT OF ITS ANTAGONIST MCPG
- VernacularTitle:次声作用后鼠脑CA_1区mGluR1?表达改变及其拮抗剂MCPG的作用研究
- Author:
Zhigang LI
;
Zhou FEI
;
Xian ZHANG
- Publication Type:Journal Article
- Keywords:
infrasound;
mGluR1?;
brain injury;
MCPG
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the change in mGluR1? in CA 1 after infrasonic damage and the effect of its antagonist MCPG,120 SD rats were randomizied into infrasonic damage group and MCPG therapy group.The two groups were subdivided into control group and 1 challenge, 7 chellenges, 14 challenge groups respectively,each group consisted of 15 rats. Rats were exposed to 8Hz 130dB infrasound as designed,2h for each challenge.The mGluR1? was stained by immunohistochemistry method.The changes in mGluR1? and cell pattern were observed under light and electronic microscopes.The results showed the number of mGluR1? positive neurons increased after 1 challenge infrasonic damage( P 0 05).MCPG had an effect to protect neuron from infrasonic damage as identified by morphology.It is concluded that the change of mGluR1? activity could mediate excitotoxicity and was one of the major factors related with neuron injury after infrasound.
