USAGE OF DONOR STEM CELL INFUSION IN PATIENTS AFTER NONMYELOABLATIVE PROCEDURE
- VernacularTitle:供者动员后造血干细胞输注在非清髓异基因造血干细胞移植中的应用
- Author:
Jianhui QIAO
;
Huisheng AI
;
Danhon WANG
- Publication Type:Journal Article
- Keywords:
donor stem cell infusion;
nonmyeloablative allogeneic stem cell transplantation;
chimera
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the effects of donor stem cell infusion (DSI) in patients after nonmyeloablative allogeneic peripheral blood stem cell transplantation( NAPBSCT),6 patients were infused donor stem cell in+7d～+90d consisting of MNC (0.6～7.6)?10 8 /kg, CD34 + cells (0.3～3.4)?10 6 /kg,CD3 + cells (0.3～5.1)?10 8 /kg.The results showed that 5/6 patients had definite effects in promoting donor chimeras after DSI,of these 3 achieved full donor chimeras following mixed chimeras ;4/6 have graft versus leukemia(GVL)effects.No hematopoiesis aplasia was found, and only one Ⅳdegree aGVHD developed related with DSI. It was concluded that DSI have definite GVL effects and can convert mixed chimeras to full chimeras without causing GVHD and severe hematopoietic aplasia.
