RELATION BETWEEN THE CHANGE IN NITRIC OXIDE SYNTHASE(NOS)IN GASTRIC MUCOSA INDUCED BY PHYSICAL STRESS OR PSYCHOLOGICAL STRESS AND ACUTE GASTRIC MUCOSAL LESION IN RATS
- VernacularTitle:躯体性及心理性应激状态下大鼠胃粘膜NOS变化及与胃粘膜损伤的关系
- Author:
Zhaoshen LI
;
Shinan NIE
;
Xianba ZHAN
- Publication Type:Journal Article
- Keywords:
stress ulcer;
gastric mucosa;
nitric oxide synthase
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relation between the changes in nitric oxide synthase in gastric mucosa induced by physical stress and psychological stress and acute gastric mucosal lesion,Animal model was reproduced with impulsive stimulator of high voltage and stable currency.Ninety-six male SD rats were randomly divided into three groups:control, regular and irregular group.NOS activity was measured by spectrophotometry,and the degree of injury of gastric mucosa was measured by method of Nils Lambecht.Immunohistochemistry and polyantibodies of NOSⅠ,NOSⅡ,NOSⅢ were employed to investigate locations of NOS.The result showed that NOS activity was stable in normal rats but increased significantly in group of psychological stress( P
